| Date | Opponent | Result | Home / Away | Time | Location | Television |
| Oct. 31 (Wed) |
PIKEVILLE COLLEGE [Exh.] |
W 99-64 | H | 7:00 p.m. | Lexington, KY | BBSN/FSN-S |
| Nov. 3 (Sat) |
SEATTLE [Exh.] | W 82-63 | H | 8:00 p.m. | Lexington, KY | BBSN/FSN-S |
2K Sports College Hoops Classic |
||||||
| Nov. 6 (Tue) |
CENTRAL ARKANSAS | W 67-40 | (1) | 7:00 p.m. | Lexington, KY | ESPNU |
| Nov. 7 (Wed) |
GARDNER-WEBB [Rupp] |
L 68-84 | (1) | 6:00/9:00 p.m. | Lexington, KY | ESPNU |
| Nov. 21 (Wed) |
LIBERTY |
W 80-54 | H | 7:00 p.m. | Lexington, KY | FSN-S |
| Nov. 24 (Sat) |
TEXAS SOUTHERN |
W 83-35 | H | TBA | Lexington, KY | FSN-S |
| Nov. 27 (Tue) |
STONY BROOK |
W 62-52 | H | 7:00 p.m. | Lexington, KY | FSN-S |
| Dec. 1 (Sat) |
NORTH CAROLINA |
L 77-86 | H | 2:00 p.m. | Lexington, KY | ESPN2 |
| Dec. 8 (Sat) |
Indiana |
L 51-70 | A | 4:00 p.m. | Bloomington, IN | CBS |
| Dec. 15 (Sat) |
UAB [Louisville] |
L 76-79 | (2) | 2:00 p.m. | Louisville, KY | ESPN |
| Dec. 18 (Tue) |
Houston |
L 69-83 | A | 9:00 p.m. | Houston, TX | ESPN |
| Dec. 22 (Sat) |
TENNESSEE TECH |
W 69-47 | H | 1:00 p.m. | Lexington, KY | FSN-S |
| Dec. 29 (Sat) |
SAN DIEGO |
L 72-81 | H | 2:00 p.m. | Lexington, KY | ESPN2 |
| Dec. 31 (Mon) |
FLORIDA INTERNATIONAL |
W 92-49 | H | Noon | Lexington, KY | FSN-S |
| Jan. 5 (Sat) |
LOUISVILLE |
L 75-89 | H | 4:00 p.m. | Lexington, KY | CBS |
| Jan. 12 (Sat) |
VANDERBILT |
W 79-73 2OT | H | 1:30 p.m. | Lexington, KY | CBS |
| Jan. 15 (Tue) |
Mississippi State |
L 64-69 | A | 9:00 p.m. | Oxford, MS | ESPN |
| Jan. 19 (Sat) |
Florida |
L 70-81 OT | A | 9:00 p.m. | Gainesville, FL | ESPN |
| Jan. 22 (Tue) |
TENNESSEE |
W 72-66 | H | 9:00 p.m. | Lexington, KY | ESPN |
| Jan. 26 (Sat) |
SOUTH CAROLINA |
W 78-70 | H | 1:00 p.m. | Lexington, KY | Lincoln |
| Feb. 2 (Sat) |
Georgia |
W 63-58 | A | 1:00 p.m. | Athens, GA | CBS |
| Feb. 6 (Wed) |
Auburn |
W 66-63 | A | 8:00 p.m. | Auburn, Alabama | Lincoln |
| Feb. 9 (Sat) |
ALABAMA |
W 62-52 | H | 1:00 p.m. | Lexington, KY | Lincoln |
| Feb. 12 (Tue) |
Vanderbilt |
L 52-93 | A | 9:00 p.m. | Nashville, TN | CBS |
| Feb. 16 (Sat) |
LSU |
W 67-63 | A | 1:00 p.m. | Baton Rouge, LA | Lincoln |
| Feb. 19 (Tue) |
GEORGIA |
W 61-55 | H | 9:00 p.m. | Lexington, KY | ESPN |
| Feb. 23 (Sat) |
ARKANSAS |
W 63-58 | H | 2:00 p.m. | Lexington, KY | CBS |
| Feb. 27 (Wed) |
OLE MISS |
W 58-54 | H | 8:00 p.m. | Lexington, KY | Lincoln |
| Mar. 2 (Sun) |
Tennessee |
L 60-63 | A | Noon | Knoxville, TN | CBS |
| Mar. 5 (Wed) |
South Carolina |
W 71-63 | A | 7:00 p.m. | Columbia, SC | Lincoln |
| Mar. 9 (Sun) |
FLORIDA |
W 75-70 | H | Noon | Lexington, KY | CBS |
SEC Tournament |
||||||
| Mar.15 | Georgia | L 56-60 | (3) | TBA | Atlanta, GA | Lincoln/CBS |
|
NCAA Tournament |
||||||
| Mar. 20 | Marquette | L 66-74 | (4) | TBA | Anaheim, CA | CBS |
White = Away Game
Silver = Home Game
1 = 2K Sports College Hoops Classic (Rupp Arena)
2 = Freedom Hall, Louisville, KY
3 = Georgia Dome (Atlanta, Ga.)
4 = NCAA Tournament, Anaheim, CA